Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME)

Recruiting

Interventions: Diagnostic Test: Imaging, blood samples, fuctional tests and physical examination

Brief Summary: Almost 90% of systemic sclerosis (SSc) patients experience hand function limitation, which leads to impaired daily functioning and work participation. An important cause of impaired hand function are contractures of the hand, which are reported in up to a half of patients. With this longitudinal cohort study in patients with SSc and VEDOSS (very early diagnosis of systemic sclerosis) the investigators aim to gain more insight into processes involved in hand function impairment.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Patients with diabetic cheiroarthropathy and Dupuytren's disease, based on expert opinion

Arm && Interventions

Group	Intervention	Description
SSc with hand contractures	Imaging, blood samples, fuctional tests and physical examination	-
VEDOSS	Imaging, blood samples, fuctional tests and physical examination	defined as RP, presence of SSc specific autoantibodies (ACA, ATA, ARA), puffy fingers and abnormal nailfold capillaroscopy (giant capillaries or capillary loss with or without haemorrhages), but not fulfilling the EULAR-ACR 2013 classification criteria for SSc
SSc with disease duration of < 4 years without hand contractures	Imaging, blood samples, fuctional tests and physical examination	-

Primary Outcome Measures

Name	Time	Method
Determination of risk factors for hand function impairment in systemic sclerosis (SSc) patients with early disease, very early disease and established hand impairment (contractures) at 2 years follow-up	2 years

Secondary Outcome Measures

Name	Time	Method
Identify underlying mechanisms	2 years
- Validation of the Dutch PASTUL questionnaire	2 years

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