Can the drug Retinol Palmitate improve dryness and keratinization of the eye in patients with Chronic Stevens Johnson Syndrome
Not Applicable
Completed
- Conditions
- Health Condition 1: H04- Disorders of lacrimal system
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
Patients with severe dry eye and ocular surface keratinization in chronic Stevens-Johnson Syndrome
Patients willing to give consent
Exclusion Criteria
Age <18 years
Pregnancy
Presence of other ocular co-morbidities
Patients not willing to follow up
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Visual acuity <br/ ><br>Anterior and posterior segment examination <br/ ><br>Tear film breakup time <br/ ><br>Schirmers test <br/ ><br>Tear film height (ASOCT) <br/ ><br>Epithelial Mapping on ASOCT (Rtvue) <br/ ><br>Impression cytology for conjunctival goblet cell density, conjunctival keratinization, corneal keratinization <br/ ><br>Tear film TGF beta and MMP-9Timepoint: Pre- treatment <br/ ><br>1 week <br/ ><br>2 weeks <br/ ><br>4 weeks <br/ ><br>8 weeks <br/ ><br>12 weeks <br/ ><br>(Impression cytology for conjunctival goblet cell density, conjunctival keratinisation, corneal keratinisation; and Tear film TGF beta and MMP-9 will be performed pre treatment, 1 week, 4 weeks and 12 weeks only)
- Secondary Outcome Measures
Name Time Method OSDI QuestionnaireTimepoint: Pre- treatment <br/ ><br>1 week <br/ ><br>2 weeks <br/ ><br>4 weeks <br/ ><br>8 weeks <br/ ><br>12 weeks