To compare efficacy and safety of continuous and intermittent Ryles tube feeding in critically ill patients in terms of achieving target nutrition goal and tolerance of feed.

Phase 2

Conditions: Health Condition 1: R69- Illness, unspecified

Registration Number: CTRI/2024/07/071278

Lead Sponsor: Fortis Escorts hospital Jaipur

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Yet Recruiting

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1.Adult patients 18 to 80 years admitted to the intensive care unit (MEDICAL ICU)

2.Patients receiving mechanical ventilation,who expected to require ventilation for greater than or equal to72 hrs and where to start enteral tube feeding with in 48 hrs of the icu admission.

3.Hemodynamically stable patients.

4.BMI is 18 to 50

5.Patient’s relative giving consent

Exclusion Criteria

1.Patients with contraindications to enteral feeding, such as severe diarrhea greater than one litre in 24hrs,acute pancreatitis,bowel ischemia,bowel obstruction,history of upper GI surgery,malabsorption syndrome,GI bleeding,short bowel syndrome.

2.Pregnancy or lactation.

3.Presence of a percutaneous endoscopic gastrostomy (PEG) or jejunostomy tube.

4.Anticipated need for surgical intervention during the study period.

5.Hypersensitivity reactions to prokinetic agents

6.Abdominal surgery with in one month.

7.Difficulty in placement of nasogastric or orogastric tube.

8.Ongoing enteral nutrition on admission to MICU.

9.Patient’s relatives not giving consent

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be Mean duration to achieve at least 70% of the target nutrition requirement after the start of enteral feeding(in hours). The achievement rate will be calculated as the number of days in which at least 70% of the target nutrition requirement is achieved divided by the total number of days of feeding days. Gastrointestinal intolerance during the first 7 days after the start of enteral feedingTimepoint: Enteral feeding will be initiated with in 48 hours of ICU admission after randomization.Target nutrition will be achieved as early as possible and study will monitor patient for seven days for target achieved.

Secondary Outcome Measures

Name	Time	Method
Secondary endpoints will include ICU mortality, 28-day mortality, length of stay in the ICU and hospitalTimepoint: Secondary endpoints will include ICU mortality, 28-day mortality, length of stay in the ICU and hospital