Pharmacokinetic and pharmacodynamic target attainment of cefuroxime in adult patients on general wards with different degrees of renal function: a prospective observational cohort study
Recruiting
- Conditions
- InfectionsRenal impairment1000401810038430
- Registration Number
- NL-OMON52078
- Lead Sponsor
- oordwest Ziekenhuisgroep
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
Receiving cefuroxime therapy intravenous (iv) as part of standard care
Age >= 18 years
Admitted to a general ward of Noordwest Ziekenhuisgroep location Alkmaar
Informed consent is obtained
Exclusion Criteria
Mentally incapacitated patients , i.e. a minor or legally incompetent adult
Renal replacement therapy during treatment with cefuroxime
Patients admitted to the intensive care unit (ICU)
Severely burned patients, defined as a burned surface >= 10%
Patients with cystic fibrosis
Informed consent is not obtained
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Percentage of patients attaining the cefuroxime PK-PD target of 50%T>MIC. This<br /><br>will be investigated for patients with adequate renal function receiving a<br /><br>regular cefuroxime dose and impaired renal function receiving a guideline<br /><br>recommended reduced dose.</p><br>
- Secondary Outcome Measures
Name Time Method