Pharmacokinetic and pharmacodynamic target attainment of ceftazidime in adult patients on general wards with different degrees of renal function: a prospective observational cohort study.
- Conditions
- Bacterial infections
- Registration Number
- NL-OMON25634
- Lead Sponsor
- Amsterdam UMC - location Academic Medical Centre (AMC), University of Amsterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Receiving ceftazidime therapy intravenous (iv) as part of standard care
Age = 18 years
Admitted to a general ward of Amsterdam UMC - location AMC
Informed consent is obtained
Exclusion Criteria
Renal replacement therapy during treatment with ceftazidime
Patients admitted to the intensive care unit (ICU)
Severely burned patients, defined as a burned surface = 10%
Patients with cystic fibrosis
Informed consent is not obtained
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PK-PD target attainment of 50%T>MIC during the first 24 hours of therapy
- Secondary Outcome Measures
Name Time Method 50%T>MIC after 24-48 hours of therapy<br>PK-PD target attainment of 100%T>MIC during the first 24 hours of therapy<br>To compare ceftazidime exposure at 24 hours and 24-48 hours after start of treatment between three different renal function groups in terms of AUC and Cmin<br>Clinical outcome