Prediciton of renal response to intravenous fluid administration by passive leg raising and stroke volume variation in critically ill patients.

Recruiting

• Conditions: Vloeistofovervulling; Acute kidney injury/acute tubulus necrosis and fluid overload; 10038430

• Registration Number: NL-OMON46898
• Lead Sponsor: Medisch Centrum Alkmaar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 35

Inclusion Criteria

- Mechanically ventilated patients of both gender
- Age 21 years and under 80 years of age
- admitted to the intensive care unit (ICU) with oliguria (<0.5 ml/kg/hr) after the initial resuscitation period at the ICU defined by: no or low increase (less than 25%) in vasopressor medication in the past 2 hour before inclusion and fluid administration less than 500 ml Ringers* lactate per hour.

Exclusion Criteria

- medical grounds: the physician requires to deviate from current protocol to adequately treat other life threatening events.
- ethical grounds: e.g. pre-terminal illness
- Loss of blood >100 ml per hour
- relevant alterations in inotropic or vasopressor medication.
- Use of clinically relevant diuretics (furosemide, bumetanide, hydrochloorthiazide during the research protocol)
- a known medical history of significant heart failure requiring daily administration of high dose diuretics.
- pulmonary edema.
- pregnancy
- practical drawbacks

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The study parameters are: SVV, stroke volume (SV) and cardiac output (CO),<br /><br>static haemodynamic parameters including SvO2, lactate, diuresis and urinary<br /><br>indices. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>For the substudy fluid in the lungs will be assessed by looking at artefacts<br /><br>with lung ultrasound.</p><br>