Renal fluid responsiveness in oliguric critically ill patients

Completed

• Conditions: low diuresis; low urine output; 10038430

• Registration Number: NL-OMON40185
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

- * 18 years of age
- Informed consent
- Oliguria for at least 2 consecutive hours
- No diuretics administered in the past 3 hours

Exclusion Criteria

- On continuous renal replacement therapy at time of eligibility
- Pregnancy
- Positive fluid balance * 10 L at time of eligibility
- Risk or evidence of pulmonary edema
- Risk or evidence of heart failure or coronary illness
- pH < 7.25 or base excess < -10
- Already included into this study more than 2 times.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is renal fluid responsiveness after fluid therapy.<br /><br>Fluid responsiveness is defined as an increase in urine output to * 0.5 ml/kg/h<br /><br>after fluid therapy, and fluid unresponsiveness is defined as persistance of<br /><br>oliguria after fluid therapy. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Hemodynamic, urine and plasma parameters will be collected to identify possible<br /><br>predictors of renal fluid responsiveness, and patients will be followed till<br /><br>the 28th day after inclusion or discharge to identify possible differences in<br /><br>renal outcome between groups.</p><br>