FunctiOnal lIver MicrocIrculation measured by SorbiTol and Indocyaninegreen plasma Clearance, the OptIMISTIC- study.

Withdrawn

• Conditions: sepsis; Liver failure (liver transplant patients); hemihepatectomy for cancer; sepsis.; 10019654

• Registration Number: NL-OMON38110
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

• ;o Age 18 years or older.;o Informed consent of the test person or from her/his lawful representative.;o Patients admitted for liver transplant, hemi-hepatectomy for primary or secondary liver malignancy, or sepsis. ;The control group will be recruited from patients admitted for subarachnoid bleeding without liver disease.

Exclusion Criteria

• ;o No informed consent.;o Allergy for the administered substances, including inborn errors of the *fructose-pathway*.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study objectives;<br /><br>The main study objective is the clinical use of D-sorbitol plasma clearance as<br /><br>a measure of functional liver blood flow.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>