Study of expression of and immunity against neoantigens in patients with constitutional mismatch repair deficiency (CMMR-D) syndrome

Completed

• Conditions: bi-allelic Lynch syndrome; Biallelic MisMatch Repair Deficiency (BMMRD); 10027664; 10027655

• Registration Number: NL-OMON49277
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Trial is onging in other countries

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-04-17
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 10

Inclusion Criteria

• Patients with genetically proven Constitutional Mismatch Repair Deficiency
(CMMRD)
• Signed informed consent

Exclusion Criteria

• Any form of comorbitity interfering with safe collection of blood
• Having objectives against coded storage of tissue

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoints of the study are the identification of neoantigens on<br /><br>different tumors of CMMR-D patients and the detection of pre-existing immune<br /><br>responses against neoantigens<br /><br><br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>