Multidrug Resistance After Trabeculectomy With Mitomycin C

Completed

• Conditions: Glaucoma; Trabeculectomy

• Registration Number: NCT00449631
• Lead Sponsor: University of Cologne

Brief Summary

We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.

Detailed Description

Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

Study Timeline

• Status Verified: 2007-03
• Study First Submitted: 2007-03-19
• Study First Submitted QC: 2007-03-19
• Study First Posted: 2007-03-20
• Last Update Submitted: 2007-03-23
• Last Update Posted: 2007-03-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• patients with planned trabeculectomy for elevated eye pressure
• one third of patients without previous trabeculectomy
• two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

Exclusion Criteria

• patients not requiring surgery
• patients with planned surgery for elevated eye pressure other than trabeculectomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

The University Hospital of Cologne; 🇩🇪 Cologne, Germany