Effects of Different Revascularization Strategies on Cardiovascular Outcomes in Patients With Complex Coronary Artery Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Artery Disease
- Sponsor
- Beijing Anzhen Hospital
- Enrollment
- 2864
- Primary Endpoint
- MACCE
- Last Updated
- 4 years ago
Overview
Brief Summary
Coronary heart disease is one of the most serious diseases that endanger people's health. Complex coronary artery disease is critical and has high mortality. Therefore, it is urgent to explore the best treatment method for complex coronary artery disease. Some previous studies have shown that patients with left main coronary artery disease with a SYNTAX score> 32 points, and diabetic/non-diabetic three-vessel disease patients with coronary heart disease with a SYNTAX score > 22 points, CABG is recommended for revascularization. However, with the continuous innovation of surgical technology and the rapid development of surgical instruments, the treatment of patients with complex coronary artery disease is increasing. Therefore, it is necessary to investigate the effects of different revascularization strategies on long-term prognosis in patients with complex coronary artery disease (SYNTAX score > 22 points).
Investigators
Yujie Zhou
Principal Investigator
Beijing Anzhen Hospital
Eligibility Criteria
Inclusion Criteria
- •Male/female aged 18-80 years;
- •Having complex coronary artery disease (SYNTAX score \> 22 points) undergoing myocardial revascularization
Exclusion Criteria
- •Cardiogenic shock or hemodynamic instability;
- •Undergoing other heart surgery at the same time;
- •Previous coronary artery bypass surgery;
- •History of cerebral hemorrhage;
- •Ischemic stroke in the past six months;
- •History of cancer;
- •Life expectancy no more than 12 months
Outcomes
Primary Outcomes
MACCE
Time Frame: 1 year
Major adverse cardiovascular and cerebrovascular events (MACCE) at 1 year, including all-cause death, non-fatal myocardial infarction, ischemia-driven revascularization, and non-fatal stroke
Secondary Outcomes
- The composite endpoints including cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke(1 year)
- Cardiovascular death(1 year)
- All cause death(1 year)
- The composite endpoints including all-cause death, non-fatal myocardial infarction, and ischemia-driven revascularization(1 year)
- All bleeding events defined by the BARC bleeding criteria(1 year)
- The composite endpoints including cardiovascular death or nonfatal myocardial infarction(1 year)
- Type 2, 3 and 5 bleeding events defined by the BARC bleeding criteria(1 year)
- Non-fatal myocardial infarction(1 year)
- Non-fatal stroke(1 year)
- Ischemia-driven revascularization(1 year)