Intracytoplasmic Morphologically Selected Sperm Injection and Advanced Maternal Age
- Conditions
- Female Infertility
- Registration Number
- NCT01620346
- Lead Sponsor
- Sapientiae Institute
- Brief Summary
The objective of this study was to evaluate the advanced maternal age as a rationale for performing intracytoplasmic morphologically selected sperm injection (IMSI).
This prospective randomized study included couples undergoing intracytoplasmic sperm injection (ICSI) as a result of advanced maternal age (≥ 37 years old). Couples were randomly allocated to receive one of two sperm selection procedures (ICSI, n = 33; or IMSI, n = 33). The groups were compared with regard to fertilization rate, percentage of high-quality embryos, implantation, pregnancy and miscarriage rates.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 66
- Good physical and mental health
- Advanced maternal age (≥ 37 years old)
- Regular menstrual cycles of 25-35 days
- Normal basal FSH and LH levels
- Body mass index less than 30 kg/m2
- Presence of both ovaries
- Intact uterus
- No hormone therapy for at least 60 days preceding the study
- Polycystic ovaries
- Endometriosis
- Gynaecological/medical disorders
- Positive result in a screening for sexually transmitted diseases
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Implantation rate 6 weeks after embryo transfer Number of embryos implanted in the uterus divided for the number of embryos transferred.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Fertility - Assisted Fertilization Center
🇧🇷São Paulo, Brazil
Fertility - Assisted Fertilization Center🇧🇷São Paulo, Brazil