Management of pain in the arthritic knee

Not Applicable

Completed

• Conditions: Relief of pain related to knee osteoarthritis; Musculoskeletal Diseases; Gonarthrosis [arthrosis of knee]

• Registration Number: ISRCTN87455770
• Lead Sponsor: General University Hospital of Patras

Brief Summary

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37041607/ (added 12/04/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-29
• Study Completion: 2023-04-15
• Last Update Posted: 24 April 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients of either sex will participate in the clinical trial as long as they have:
1. The NICE clinical criteria of primary knee OA for one or both knees:
1.1. Age >45 years
1.2. Activity-related joint pain
1.3. No morning joint stiffness or morning stiffness that lasts no longer than 30 minutes
2. Radiological confirmation of knee arthritis (grade =2) according to the Kellgren and Lawrence classification
3. Chronic knee pain for a minimum duration of 6 months
4. Pain intensity =4 on the (NRPS)
5. A decrease of =50% in NRPS scores with diagnostic genicular nerve block
6. The ability to communicate in Greek

Exclusion Criteria

1. inflammatory or post-traumatic knee arthritis
2. Patients who have received CRYON or CRFA treatment in the past
3. Injection of hyaluronic acid or corticosteroid within the previous 3 months
4. Significant structural deformities affecting locomotion and knee function aside from osteoarthritis and which might cause chronic knee pain
5. Body mass index =40 kg/m²
6. Uncontrolled serious disease (cancer, diabetes, end-stage heart disease etc)
7. Unstable psychiatric illness
8. Coagulopathy or bleeding disorders
9. Active systemic or local infection
10. Disease-associated with reactions to cold, such as cryoglobulinemia

Study & Design

• Study Type: Interventional
• Study Design: Not specified