Colchicine Has Anti-diabetic Effect

Completed

• Conditions: Treatment Adherence
• Interventions: Drug: Colchicine Tablets

• Registration Number: NCT04377321
• Lead Sponsor: Ministry of Health and Population, Egypt

Brief Summary

Colchicine has antidiabetic effect and may be an option for type 2 diabetes management

Detailed Description

Observational cohort prospective study with following of 150 newly diagnosed type 2 diabetes patients who were in 3 groups, had been monitored in a private clinic, each group 50 patients number, with 30 females and 20 males after written consent from all patients. The ages of all patients were between 35 and 55 years.

The aim of this study was to evaluate colchicine effect on A1C of newly diagnosed type2 diabetes compared to the metformin and control group on diet only.

The first group patients received colchicine 0.5twice daily for 6 months, the second group received metformin 1gm twice daily, the third group patients were on diet only. During the period of treatment, the investigators followed the patients if there were side effects of the drugs used. No side effects were monitored during the period of treatment except for gastric upset in some patients using metformin

Study Timeline

• Study Start: 2019-10-10
• Status Verified: 2020-05
• Primary Completion: 2020-05-01
• Study Completion: 2020-05-02
• Study First Submitted: 2020-05-02
• Study First Submitted QC: 2020-05-05
• Last Update Submitted: 2020-05-05
• Study First Posted: 2020-05-06
• Last Update Posted: 2020-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• type 2 diabetes newly diagnosed age 35- 55 years

Exclusion Criteria

• severe anemia hypothyroidism and hyperthyroidism moderate to severe liver or kidney disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group 1 on cochicine	Colchicine Tablets	The first group patients received colchicine 0.5 twice daily for 6 months
group 3 control	Colchicine Tablets	the third group patients were on diet only for 6 months
group 2 on glucophage 1 gm twice daily	Colchicine Tablets	second group received glucophage 1gm twice daily for 6 months

Primary Outcome Measures

Name	Time	Method
colchicine for treatment of type diabetes patients	6 months	colchicine tablets .5 mg twice daily for 6 months

Trial Locations

Locations (1)

Mahmoud Younis; 🇪🇬 Cairo, Egypt