Postprandial bile acid metabolism in the brai

Completed

• Conditions: impaired glucose tolerance; type 2 diabetes mellitus; 10018424

• Registration Number: NL-OMON43907
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

Scheduled to undergo planned lumbar puncture.
Age 18 +, ability to give consent, BMI 19-30, normal liver and renal function

Exclusion Criteria

- Acutely ill
- DM2 (defined as HbA1C > 48 mmol/mol)
- Use of medication that influences BA metabolism (ursochol, colesevelam, colestimide, statins)
- History of allergy or intolerance to one of the components of the standard meal
- Alcohol use >2 units per day

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>bile acid levels in CSF (fasted vs fed)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>plasma insulin, glucose and bile acid levels, GLP-1 levels.</p><br>