Clinical significance of serum chemokine levels (CCL11 / CCL22 / TARC) in patients with type 2 diabetes
Not Applicable
- Conditions
- Type 2 diabetes
- Registration Number
- JPRN-UMIN000040631
- Lead Sponsor
- Department of Endocrinology and Metabolism, Dokkyo Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1)Type 1 diabetes 2)Liver dysfunction (hepatic enzymes more than three times the upper limit of normal ranges) 3)A pregnant woman and/or a woman under breast-feeding 4)Impaired kidney function (serum crearinine greater than 1.3 mg/dl in men, 1.2 mg/dl in women) 5)Diabetic proliferative retinopathy 6)The patients who has an anamnesis of hypersensitivity to the ingredient of a trial drug 7)Patient with intolerance of medical reasons by doctor.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical significance of serum chemokine levels in patient with diabetes and diabetic neuropathy.
- Secondary Outcome Measures
Name Time Method Time of measurement: early in the morning, fasting Measurement items (LSI): CCL11 (eotaxin) CCL22 (MDC) IL-6 IL-18 Urine Metabolomics U-NGAL serum: FGF21 BDNF HMW adiponectin IL-33s TNF-R1 & -R2 Relationship with diabetic complications: peripheral neuropathy: staging, nerve conduction test, CVR-R Orthostatic hypotension (Sheron test) Timed up and Go test, Monofilament Nephropathy: eGFR UAE Retinopathy: Stage Relationship with insulin resistance: BMI, InBody, DualScan Relationship with arteriosclerosis: CAVI / ABI FMD carotid IMT Routine examination at admission + IgE + TARC + Beta-hydroxyl-butyrate + M2BPG (i Mac-2 binding protein sugar chain modification isomer), Ca, P, active Vitamin D3 Heart rate variability (HRV): CVR-R, power spectrum analysis (PSA) The severity of diabetic kidney disease Coagulation fibrinolysis system: vWF, d dimer, etc. Arterial stiffness: PWV, CAVI abdominal echo