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Clinical Trials/NCT05524116
NCT05524116
Completed
Not Applicable

Telehealth Exercise and Mindfulness for Pain in Osteoarthritis: A Feasibility Study

Boston University Charles River Campus1 site in 1 country45 target enrollmentOctober 4, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Knee Osteoarthritis
Sponsor
Boston University Charles River Campus
Enrollment
45
Locations
1
Primary Endpoint
Attendance
Status
Completed
Last Updated
last year

Overview

Brief Summary

This is a parallel-arm mixed-methods randomized controlled trial to investigate the feasibility of telehealth delivered mindful exercise vs. usual exercise interventions for people with knee osteoarthritis.

Detailed Description

In this RCT, the feasibility of an 8-week telehealth mindful exercise intervention compared to an 8-week telehealth exercise only intervention for people with knee osteoarthritis (OA) will be assessed. Forty adults with knee OA will be assigned to either a mindful exercise arm OR exercise arm. Both interventions will be delivered via real-time videoconferencing in a group setting (n=8-10 per group). All participants will be administered questionnaires for self-reported symptoms, mood, quality of life, etc. throughout the study period. Participants will be given the choice to opt in for in-person data collection visits wherein their physical function, muscle strength, sensitivity to painful stimuli, and brain function will be assessed before and at the end of the interventions. At the end of the 8-week interventions, 10 participants will be purposively sampled from each arm (n=20 total) for individual interviews to determine acceptability of the telehealth interventions. Feasibility of the intervention will be determined post-intervention by outcome measures such as recruitment rate, retention rate, and adherence.

Registry
clinicaltrials.gov
Start Date
October 4, 2022
End Date
July 3, 2023
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Boston University Charles River Campus
Responsible Party
Principal Investigator
Principal Investigator

Deepak Kumar

Assistant Professor

Boston University Charles River Campus

Eligibility Criteria

Inclusion Criteria

  • Meet National Institute for Health and Clinical Excellence clinical guidelines for knee osteoarthritis (i.e., age ≥ 50 years, presence of activity related pain, presence of morning knee stiffness ≤ 30 minutes)
  • Knee pain on most days for 3 months or more
  • Average overall knee pain severity of ≥= 4 on a 11-point numeric rating scale during previous week
  • Able to attend remote sessions
  • Can speak and understand English at a sufficient level to understand the study procedures and informed consent.
  • Available for study duration

Exclusion Criteria

  • Contraindications to exercise
  • Other pain in lower back or legs that is greater than knee pain
  • Received physical therapy treatment for knee OA in the past 6 months or currently receiving physical therapy
  • Received any mindfulness programs such as Tai Chi, meditation, etc. in the past 6 months or currently receiving such program
  • Currently receiving chemotherapy or radiation therapy for cancer except non-melanoma skin cancer
  • History of other disease that may involve the index joint including inflammatory joint disease such as rheumatoid arthritis, seronegative spondyloarthropathy (eg, ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease related arthropathy), crystalline disease (eg, gout or pseudogout), lupus erythematosus, knee joint infections, Paget's disease affecting the knee, or knee joint tumors.
  • Any knee surgery in the previous 6 months
  • Joint replacement in either hip or ankle
  • Previous knee osteotomy partial or total knee replacement in either knee
  • Planned major treatment for knee OA (e.g., surgery, injections, physical therapy) during the study period

Outcomes

Primary Outcomes

Attendance

Time Frame: post-intervention (at 8-weeks)

Proportion of sessions attended

Retention Rate

Time Frame: post-intervention visit (at the end of 8-weeks)

Proportion of participants who complete patient-reported outcome surveys

Recruitment

Time Frame: through the recruitment process, up to 6 months from the start of the study

Number of participants that are randomized for the study

Participant Feedback Survey

Time Frame: 8-week

Custom scale measuring feedback on interventionists and interventions. Scores range from 0-4 (0 - Strongly Disagree, 1 - Disagree, 2 - Neither Agree no Disagree, 3 - Agree, and 4 - Strongly Agree)

Satisfaction Scale

Time Frame: 8-week

Custom 4-item (0-10 scale) to determine satisfaction with individual components of the intervention (i.e.,, exercise, mindfulness, telehealth, and overall satisfaction). There are 4 items and each item is scored separately. Higher scores for each item mean greater satisfaction for that dimension.

Secondary Outcomes

  • Knee Injury and Osteoarthritis Outcome Score(baseline, 8-week, 14-week)
  • Pain, Enjoyment, General Activity Scale(baseline, 8-week, 14-week)
  • Numeric Rating Scale - Nominated Activity(baseline, 8-week, 14-week)
  • Participant Global Impression of Change(8-week, 14-week)
  • Patient Global Assessment of Osteoarthritis(baseline, 8-week, 14-week)
  • Pain Catastrophizing Scale(baseline, 8-week)
  • Widespread Pain Index Symptom Severity Scale(baseline, 8-week)
  • Pain DETECT(baseline, 8-week)
  • Patient Health Questionnaire 8-item(baseline, 8-week, 14-week)
  • Cognitive and Affective Mindfulness Scale - Revised(baseline, 8-week, 14-week)
  • Fear Avoidance Beliefs Questionnaire - Physical Activity(baseline, 8-week)
  • Arthritis Self Efficacy Scale(baseline, 8-week)
  • Chronic Pain Self-efficacy Questionnaire(baseline, 8-week)

Study Sites (1)

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