ew bone marrow aspirate therapy for managing knee osteoarthritis

Not Applicable

Completed

• Conditions: Knee osteoarthritis; Musculoskeletal Diseases; Gonarthrosis [arthrosis of knee]

• Registration Number: ISRCTN69838191
• Lead Sponsor: The VAD Foundation

Brief Summary

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36582935/ (added 03/01/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-06-06
• Study Start: 2021-11-30
• Last Update Posted: 16 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Patients willing and able to give informed consent
2. Age 30-80 years
3. Body mass index <35 kg/m²
4. Symptomatic knee OA grade II or III diagnosed by radiographic Kellgren and Lawrence
5. History of at least 6 months of conservative treatment and no improvement of symptoms*
6. Evidence of edema-like marrow signals by MRI
7. Patients medically able to undergo carboplasty
8. Patients willing and able to follow the rehabilitation protocol

Exclusion Criteria

1. Prior history of articular infection
2. Prior history of knee arthroscopy
3. Chronic use of anticoagulation
4. Patients diagnosed with cancer or currently undergoing chemotherapy
5. Patients unable to undergo MRI
6. Patients who are pregnant or intend to become pregnant during the first year after initial enrollment
7. History of autoimmune disease
8. Evidence of HIV or chronic hepatitis B or C viral infections
9. Current drug or alcohol abuse
10. Patients deemed by the investigator as unlikely to comply with the protocol
11. Vascular or neurological abnormalities affecting the lower extremities
12. Any form of inflammatory arthritis
13. Uncontrolled systemic disease (diabetes mellitus, hyperthyroidism, etc)

Study & Design

• Study Type: Interventional
• Study Design: Not specified