Clinical Study on the Effect of Physical Activity on Cognition and Memory in the Elderly
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition
研究概览
简要总结
Physical activity is thought to increase overall body functions and to decrease cardiovascular and stroke risk factors. Now the question arose, wether enhanced exercise could also exert positive influence on cognition in the aging brain. Therefore, 50 to 80 years old healthy subjects take part in a prospective study with regular sports activity during 6 months. Cognitive functions are detected with sensitive neuropsychological outcome measures, further investigations include MRT of the head, lactat- and other physical measures as well as detailed serum profiles. As a hypothesis, enhanced physical activity is suggested to predict better cognitive performance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •50-80 years old
- •lesser activity
排除标准
- •regular physical activity
- •heavy smoking, drinking,
- •BMI < 20
- •MMSE < 25
研究组 & 干预措施
Aerobic Exercise
干预措施: exercise (Behavioral)
Anaerobic Exercise
干预措施: exercise (Behavioral)
Unchanged condition
结局指标
主要结局
Change of reaction times in ms in a motor learning task after 6 months of intervention/control condition
时间窗: 6 months
Change of delayed memory scores in #of words in a Verbal learning task after 6 months of intervention/control condition
时间窗: 6 months
Change of performance in ms in a reaction time task after 6 months of intervention/control condition
时间窗: 6 months
Change of relative regional grey matter volumes in % measured by T1-weighted MRI after 6 months of intervention/control condition
时间窗: 6 months
次要结局
- Change of physical measurements (ECG)/fitness assessments (lactate) after 6 months of intervention/control condition(6 months)
- Change of BDNF blood serum levels in ng/dl after 6 months of intervention/control condition(6 months)