ISRCTN04386758已完成未知
Optimisation of peri-operative cardiovascular management to improve surgical outcome: open randomised controlled multi-centre trial
Barts and The London School of Medicine and Dentistry, Queen Mary's University of London (UK)0 个研究点目标入组 734 人开始时间: 2009年7月24日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 734
研究概览
简要总结
2014 results in: http://www.ncbi.nlm.nih.gov/pubmed/24842135 2019 results in: http://www.ncbi.nlm.nih.gov/pubmed/30850406 (added 11/03/2019) 2019 substudy results in: https://www.ncbi.nlm.nih.gov/pubmed/31633603 (added 22/10/2019) 2019 analysis in https://www.ncbi.nlm.nih.gov/pubmed/30850406 (added 31/03/2020)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Adult patients undergoing major abdominal surgery involving the gastrointestinal tract which is expected to take longer than 90 minutes are eligible for recruitment provided they satisfy one of the following additional criteria:
- •1. Urgent or emergency surgery
- •2. Acute or chronic renal impairment
- •3. Diabetes mellitus
- •4. Aged 65 years and older, either sex
- •5. Presence of a risk factor for cardiac or respiratory disease
排除标准
- •Current exclusion criteria as of 03/05/2012
- •1. Patients receiving palliative treatment only
- •2. Acute myocardial ischaemia at time of enrolment
- •3. Pulmonary oedema at time of enrolment
- •4. Moderate/severe thromocytopenia (platelet count <50 x 109/l)
- •5. Patients receiving monoamine oxidase inhibitors (MAOIs)
- •6. Phaechromocytoma
- •7. Severe left ventricular outlet obstruction, e.g. hypertrophic obstructive cardiomyopathy or severe aortic stenosis
- •8. Known hypersensitivity to dopexamine hydrochloride or disodium edenate
- •9. Pregnancy
- •10. Septic shock
- •Previous exclusion criteria
- •1. Patients receiving palliative treatment only
- •2. Acute myocardial ischaemia at time of enrolment
- •3. Pulmonary oedema at time of enrolment
- •4. Moderate/severe thromocytopenia
- •5. Patients receiving monoamine oxidase inhibitors (MAOIs)
- •6. Phaechromocytoma
- •7. Severe left ventricular outlet obstruction, e.g. hypertrophic obstructive cardiomyopathy or severe aortic stenosis
- •8. Known hypersensitivity to dopexamine hydrochloride or disodium edenate
- •9. Pregnancy
研究者
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