The PEPaNIC long-term outcome study: Neurocognitive developmental deficit after critical illness in children: role of modifiable epigenetic changes
Completed
- Conditions
- Kinderen die kritiek ziek zijn geweest en behandeld op Intensive CareCritical illness / malnutrition
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 885
Inclusion Criteria
The children who are participants in the PEPaNIC study are all eligible for the long-term outcome study.
Healthy controls, recruited for an identical follow-up programme, will be demographically (primarily age, gender and ethnicity) matched to the PEPaNIC study participants.
The inclusion criteria for the healthy controls are:
* Same gender proportion as the cases
* Same age range as the cases
* Same social-economic status
Exclusion Criteria
No exclusion criteria, other than 'no consent', are applicable for the PEPaNIC patients. The exclusion criteria for the healthy controls are:
* History of neonatal or paediatric intensive care admission
* History of parenteral nutrition
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary goal of the PEPaNIC long-term outcome study is to determine the<br /><br>long-term neurocognitive outcome (more specifically the IQ-scores, motor and<br /><br>executive function) of critical illness and the effect hereon of artificial<br /><br>nutrition provided during the acute phase of critical illness in children. </p><br>
- Secondary Outcome Measures
Name Time Method <p>to determine the effect on:<br /><br>-anthropometrics (legnth, weight, arm-leg circumference)<br /><br>-neuro-endocrine axes (hair, blood)<br /><br>-epigenetic modifications (white blood cells / saliva / mucosal swab)<br /><br>-health economics; eg healthy care consumptions, CUA etc.<br /><br>-endurance/activity</p><br>