Mannitol inhalations as faster procedure for testing of airways hyper-responsiveness

niversity Medical Center Groningen (UMCG) (The Netherlands)0 个研究点目标入组 120 人开始时间: 2006年11月22日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•Asthmatics:
•1. Episodic symptoms of dyspnea, and/or wheezing, and/or cough
•2. Allergic or non-allergic
•3. Non current smokers (more than 0.5 years)
•4. Provocation Concentration that causes a decrease in forced expiratory volume in one second of 20% (PC20) for MethaCholine (MCh) less than 8 mg/ml
•Chronic Obstructive Pulmonary Disease (COPD) patients:
•1. Age more than 40 years
•2. Active or former smokers, with a smoking history of more than ten pack years
•3. Continuous symptoms of cough/sputum and/or dyspnea on exertion
•4. No history of asthma
•5. Forced expiratory volume in one second (FEV1)/Forced Vital Capacity (FVC) less than 70% and FEV1 between 50 and 80% predicted
•1. No history of asthma or COPD
•2. PC20 MCh more than 8 mg/ml
•3. FEV1/FVC more than 70% and FEV1 more than 90% predicted

•1. Age less than 18 years
•2. Inability to perform acceptable-quality spirometry or to understand directions given by personnel
•3. Severe airflow limitation (FEV1 less than 50% of predicted or less than 1.0 L)
•4. Heart attack or stroke in last three months
•5. Uncontrolled hypertension, systolic Blood Pressure (BP) more than 200 mmHg, or diastolic BP more than 100 mmHg
•6. Known aortic aneurysm
•7. Pregnancy
•8. Nursing mothers
•9. Current use of cholinesterase inhibitor medication (for myasthenia gravis)

发起方

niversity Medical Center Groningen (UMCG) (The Netherlands)