CTRI/2020/07/026598
Active, not recruiting
Phase 3
A prospective randomised comparative study on the efficacy and safety profile of oral and subcutaneous methotrexate in patients of moderate to severe chronic plaque psoriasis
Ishan Agrawal0 sites0 target enrollmentTBD
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- Health Condition 1: D50-D89- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Sponsor
- Ishan Agrawal
- Status
- Active, not recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patients more than 18 years of age, with clinically diagnosed and biopsy proven plaque psoriasis, who have given their consent to be included in the study.
- •2\. Patients with body surface area involvement \> 10 %, Psoriasis Area and Severity Score \>10, Dermatological Life Quality Index \>10\.
Exclusion Criteria
- •1\. Hemoglobin \< 8 gm/dl ,Total leukocyte count \<3500/mm3, Platelet count \< 100,000/mm3\.
- •2\. Elevation of hepatic enzymes (Alanine aminotransferase \[ALT], Aspartate aminotransferase \[AST], or γ glutamyltransferase \[GGT]) to more than twice the upper limit of normal.\[4]
- •3\. Hepatitis, active or recurrent,
- •4\. Cirrhosis or excessive current alcohol intake.
- •5\. Use of other hepatotoxic drugs by the patient.
- •6\. Positive Hepatitis B, Hepatitis C or HIV serology.
Outcomes
Primary Outcomes
Not specified
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