Clinical Impact on Point-of-Care Multiplex Polymerase Chain Reaction (PCR) Testing for Critically Ill Adult Patients With Community-acquired Pneumonia
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Intravenous antibiotic-free day within 14 days
研究概览
简要总结
Clinical Impact on Point-of-Care Multiplex PCR Testing for Critically Ill Adult Patients With Community-acquired Pneumonia - A cluster randomization study in ICU units within one medical center.
详细描述
Point-of-Care Multiplex PCR Testing could narrow down the pathogens causing severe community-acquired pneumonia(CAP). Our hypothesis is that the result of Point-of-Care Multiplex PCR Testing could help primary physician to reduce antibiotics use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (age >20 y/o)
- •ICU admission for acute respiratory failure due to community-acquired pneumonia by clinical diagnosis
- •Treatment with endotracheal Intubation
排除标准
- •Aspiration pneumonia (including witnessed aspiration and chronic bedridden status)
- •Nosocomial infection
研究组 & 干预措施
Reporting
check point-of-care Multiplex PCR for pneumonia pathogens and report results to primary care physician
干预措施: Provide the panel report to the primary care physician (Diagnostic Test)
Usual Care
check point-of-care Multiplex PCR for pneumonia pathogens but do NOT report results to primary care physician. Let primary care physician provide usual standard care
结局指标
主要结局
Intravenous antibiotic-free day within 14 days
时间窗: up to 14 days
days without intravenous antibiotics within 14 days
次要结局
- ICU stay(up to 21 days)
- Antibiotic-free day within 21 days(21 days)
- Intravenous antibiotic-free day within 21 days(up to 21 days)
- Ventilator-free day within 28 days(up to 28 days)