Low Dose Peri- Operative Intra Venous Teranexamic Acid Reduces Blood Loss After Total Knee Arthroplasty: A Double Blind Randomized Placebo Controlled Clinical Trial

Not Applicable

Completed

• Conditions: Knee Arthroplasty, Total
• Interventions: Drug: Normal saline; Drug: Tranexamic Acid

• Registration Number: NCT02327117
• Lead Sponsor: Isfahan University of Medical Sciences

Brief Summary

Total Knee Arthroplasty (TKA) is a common orthopedic surgery usually leads to Bleeding. The null hypothesis of this study was that TA has no effect on post surgical bleeding in patients undergoes TKA.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2014-12-23
• Study First Submitted QC: 2014-12-23
• Study First Posted: 2014-12-30
• Primary Completion: 2015-01
• Status Verified: 2016-06
• Results First Submitted: 2016-06-12
• Results First Submitted QC: 2016-06-12
• Last Update Submitted: 2016-06-12
• Results First Posted: 2016-07-22
• Last Update Posted: 2016-07-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Individuals with osteoarthritis who indicated for primary TKA.

Exclusion Criteria

• Previous history of ceberovascular diseases
• Previous history of myocardial infarction
• Candidates for bilateral TKA

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Normal Saline	Normal saline	-
Tranexamic acid	Tranexamic Acid	-

Primary Outcome Measures

Name	Time	Method
Hb Level 48 Hours After Total Knee Arthroplasty	48 hours after TKA

Trial Locations

Locations (1)

Amin Nemati; 🇮🇷 Isfahan, Iran, Islamic Republic of