NCT03282253Unknown不适用
Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity and Clinical Outcomes of Severe Acute Pancreatitis
Nanjing University School of Medicine0 个研究点目标入组 216 人开始时间: 2018年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 216
- 主要终点
- the incidence rate of infected pancreatic necrosis
研究概览
简要总结
In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local complications, organ failure, mortality and so on.In this prospective study, participants were divided into two groups based on serum SCD-1 concentration on admission and prospectively observe the disease severity and clinical outcomes of them.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of acute pancreatitis (Atlanta standard), abdominal pain occurred within one week of admission;
- •APACHEII score is more than 8 and Ranson score is greater than 3;
- •Obtaining informed consent.
排除标准
- •Pregnancy pancreatitis;
- •Patients with the following disease history: severe cardiac, pulmonary, renal, liver function insufficiency or immunodeficiency disease.
结局指标
主要结局
the incidence rate of infected pancreatic necrosis
时间窗: 2-4 week after disease onset
次要结局
- the incidence rate of organ failure(1-2 week after disease onset)
- the incidence rate of local complications(1-2 week after disease onset)
研究者
Weiqin Li
Director of Department of Surgical Intensive Care Unit
Nanjing University School of Medicine
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