Amyotrophic Lateral Sclerosis Registry
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Amyotrophic Lateral Sclerosis
- Sponsor
- yilong Wang
- Enrollment
- 1000
- Locations
- 1
- Primary Endpoint
- Gene Mutation Characteristics of ALS in Chinese
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This study takes amyotrophic lateral sclerosis (ALS) patients as the main research object. Through collecting genetics, imaging and clinical symptoms for Exploratory research, we will construct the gene spectrum of ALS in China, explore unknown pathogenic genes, explore the characteristic image characteristics of ALS, and establish the iPSCs library of ALS, providing resources and basis for the research of pathogenesis and treatment targets of ALS.
Detailed Description
This study is a multicenter, prospective registration study that will follow up patients with clinically confirmed and suspected amyotrophic lateral sclerosis for a period of 2 years. A total of 1000 patients will be included to dynamically observe the changes in clinical symptoms and signs, imaging, electrophysiology, biomarkers, biological samples and so on, which will construct a genetic profile of ALS in China, explore the etiology and pathogenesis, and establish an iPSCs library, provide a basis for finding treatment targets.
Investigators
yilong Wang
Vice-President of Beijing Tiantan Hospital,Chief Scientist of Neurology Center
Beijing Tiantan Hospital
Eligibility Criteria
Inclusion Criteria
- •18 years old ≤ age ≤ 80 years old;
- •Patients are diagnosed definite or probable ALS according to the Awaji diagnostic criteria;
- •Sign an informed consent form.
Exclusion Criteria
- •Unable to cooperate with research or complete follow-up due to geographical or other reasons.
Outcomes
Primary Outcomes
Gene Mutation Characteristics of ALS in Chinese
Time Frame: day 1
Constructing a Chinese ALS genetic information database by collecting genetic information from patients.
The disease development of ALS in the Chinese
Time Frame: month 24
Record the progress of patients' clinical symptoms from baseline through 2-year follow-up.
Secondary Outcomes
- Exploring the imaging characteristics of ALS in the Chinese(day 1, month 3, month 6, month 9, month 12, month 15, month 18, month 21, month 24)
- Establishing an iPSCs library for ALS in the Chinese(day 1)
- Analysis of the correlation between electrophysiology characteristics and imaging characteristics of ALS in Chinese(day 1, month 3, month 6, month 9, month 12, month 15, month 18, month 21, month 24)