Composition of stimulated and unstimulated saliva in subjects with inactive and active caries
- Conditions
- Prevention and treatment of dental caries in caries-inactive and active adultsOral Health
- Registration Number
- ISRCTN64570618
- Lead Sponsor
- Agencia Nacional de Investigación y Desarrollo
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 40
Systemically health adults between 18 and 35 years of age who are able to give their informed consent autonomously, with normal unstimulated and stimulated salivary flow rate, good general and oral health, ability to comply with the experimental protocol, no antibiotic use during the three months before the study and not using a fixed or removable orthodontic or devices.
Subjects with systemic diseases related with caries that affect the salivary flow (such as Sjögren's syndrome), who has periodontal diseases (except gingivitis), who that had taken antibiotics during the last three months, that regularly consumed alcohol or that takes medications daily known to alter salivary flow and smokers will be excluded from the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of potential protective factors in unstimulated and stimulated saliva from caries-inactive and active subjects using mass spectrometry-based proteomics at baseline, one and three months
- Secondary Outcome Measures
Name Time Method <br> Characterization of unstimulated and stimulated saliva from caries-inactive and active subjects at baseline, one and three months based on:<br> 1. Inorganic and biochemical composition measured using commercial laboratory kits<br> 2. Protein and microbial composition measured using mass spectrometry-based proteomics<br>