A study to better understand the corneal infection from patient tear and swab samples
Not Applicable
- Conditions
- Health Condition 1: H160- Corneal ulcer
- Registration Number
- CTRI/2023/05/052718
- Lead Sponsor
- nited Kingdom Research and Innovation Future Leaders Fellowship
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a) Presence of corneal ulcer: defined as a corneal epithelial defect with underlying corneal infiltrate and signs of acute inflammation
b) Appropriate written and informed consent
Exclusion Criteria
a) Less than 18 years
b) No consent
c) Suspected viral, acanthamoeba or mixed keratitis cases
d) Microbial Keratitis in both eyes
e) Use of steroids or anti-microbials for other conditions
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a) To identify biomarkers by analyzing the ocular samples (tears) of microbial keratitis patients (proteomics and metabolomics) throughout treatment course. <br/ ><br> <br/ ><br>b) To define the contribution of the associated microorganisms to disease pathogenesis by studying the micro/mycobiome(conjunctival swabs) in disease and compared with healthy controls <br/ ><br> <br/ ><br>c) To relate biomarker findings to clinical outcomesTimepoint: 12 months
- Secondary Outcome Measures
Name Time Method ilTimepoint: Nil