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Clinical Trials/NCT06472843
NCT06472843
Not yet recruiting
Not Applicable

Tailoring Upper Limb Exercise Advice for People With Parkinson Disease

University of British Columbia0 sites20 target enrollmentJuly 1, 2024

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Parkinson Disease
Sponsor
University of British Columbia
Enrollment
20
Primary Endpoint
9-hole pegboard test
Status
Not yet recruiting
Last Updated
last year

Overview

Brief Summary

The investigators will explore the impact of hand cycling, on hand function in people with Parkinson's Disease (PD). The study will compare the effects of two different hand cycling approaches-steady-state and interval efforts-on improving hand dexterity in people with PD. Conducted as a clinical trial, it aims to understand if a single session of hand cycling can temporarily enhance hand function and if the nature of the exercise influences the benefit.

Detailed Description

The purpose of this study is to examine the effects of hand cycling, an upper limb aerobic exercise, on hand function in individuals with Parkinson's Disease (PD). Parkinson's Disease affects motor skills, including hand dexterity, which can impede daily activities. While aerobic exercise is known to have benefits for people with PD, the specific impact of upper limb exercises like hand cycling on hand function is less studied. Previous research suggests aerobic exercises can improve symptoms and motor function in PD. This study aims to fill the gap in understanding how hand cycling affects hand dexterity in PD. There is no placebo involved in this study as it compares two active intervention types: steady-state and high-intensity interval hand cycling. This is a block randomized parallel group clinical trial involving a single session of exercise intervention. Participants will be randomly assigned to one of two groups: steady-state or high-intensity interval hand cycling. The study includes baseline assessments, the exercise intervention, and post-intervention assessments to evaluate changes in hand function. The primary endpoint is the time to complete the 9-hole pegboard test with the clinically more affected hand. Secondary endpoints include changes in motor examination scores, finger tapping speed, and subjective measures of exercise perception. Analysis of covariance will be used to compare the primary outcome between groups, accounting for baseline performance and clinical characteristics. The planned sample size is 20 people with PD, aiming to capture varied clinical expressions of the disease.

Registry
clinicaltrials.gov
Start Date
July 1, 2024
End Date
September 2024
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Daryl Wile

Clinical Assistant Professor, University of British Columbia Southern Medical Program

University of British Columbia

Eligibility Criteria

Inclusion Criteria

  • Adults over 19 with a clinical diagnosis of PD.

Exclusion Criteria

  • Medical contraindication to aerobic exercise, such as unstable cardiovascular disease, or physical disability that precludes arm exercise.
  • Individuals will be excluded if, upon screening with the Canadian Society for Exercise Physiology (CSEP) Get Active Questionnaire and International Physical Activity Questionnaire Short Form (IPAQ-SF) a need for further evaluation before exercise is identified

Outcomes

Primary Outcomes

9-hole pegboard test

Time Frame: Through study completion, an average of 9 months

Time to complete the 9-hole pegboard test with the clinically more affected hand.

Secondary Outcomes

  • Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) score(Through study completion, an average of 9 months)
  • Positive Affect(Through study completion, an average of 9 months)
  • Finger tapping speed(Through study completion, an average of 9 months)
  • Enjoyment(Through study completion, an average of 9 months)
  • Perceived exertion(Through study completion, an average of 9 months)

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