Physical Activity Program for Counteracting Sarcopenia

Not Applicable

• Conditions: Sarcopenia
• Interventions: Behavioral: Physical activity; Dietary Supplement: Physical activity and supplementation; Other: Control

• Registration Number: NCT04172285
• Lead Sponsor: I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio

Brief Summary

Sarcopenia is a pathophysiological process associated with aging and some metabolic conditions characterized by progressive muscle tissue loss, which may lead to loss of strangth and performance and increase risk of falls and fractures, physical disability and premature death. Therefore, it is necessary to identify personalized programs of physical activity and supplementation for elderly population in order to improve their physical functions, muscle strengh and body composition.

With the present project we aime to assess the effect of a feasible home-based exercise program coupled with food supplementation to improve muscle strength, muscle volume and muscle physical performance potentially associated with sarcopenia in elderly people.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-18
• Study First Submitted: 2019-11-13
• Study First Submitted QC: 2019-11-20
• Study First Posted: 2019-11-21
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-08
• Last Update Posted: 2021-02-09
• Primary Completion: 2021-12-20
• Study Completion: 2021-12-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Sedentary lifestyle.
• Cognitively intact.
• Autonomous walking.
• Acceptance of informed consent.

Exclusion Criteria

• Body mass index lower than 18.5 and uppen than 40 kg/m2.
• History of cancer.
• Pacemaker user.
• History of epileptic episodes.
• Endocrine-metabolic, neurological, muscular and ortopedic pathologies that affect movement functions.
• Bone fractures that influence movement functions.
• Smoking.
• Surgical treatments in the prior 6 months.
• Use of antieptilectics, glucocorticoids, rhGH and testosterone.
• Hepatic and muscular pathologies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Physical activity group	Physical activity	-
Physical activity and supplementation group	Physical activity and supplementation	-
Control group	Control	-

Primary Outcome Measures

Name	Time	Method
Lower limb strength	Baseline and Week 24	Assessed by chair stand test

Secondary Outcome Measures

Name	Time	Method
Body composition	Baseline and Week 24	Assessed by Whole-body dual energy X-ray absorptiometry
Quantify thigh cross sectional area	Baseline and Week 24	Assessed by Dixon magnetic resonance imaging
Maximum isometric force that a hand can squeeze	Baseline and Week 24	Assessed by Hand Grip Strength test
Maximal Isometric Strength of Knee flexors and extensors	Baseline AND Week 24	Assessed by a belt-stabilized dynamometer
Dynamic balance and gait deficits	Baseline and Week 24	Assessed by mini-BESTest

Trial Locations

Locations (1)

IRCCS Istituto Ortopedico Galeazzi; 🇮🇹 Milan, Italy