NCT06789978招募中不适用
Prehospital Extracorporeal Cardiopulmonary Resuscitation: a Pilot Study in Prague
General University Hospital, Prague2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2025年1月20日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Time from collapse to ECPR
研究概览
简要总结
A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA
详细描述
The aim of this pilot prospective study is to assess the feasibility and effectiveness of a prehospital extracorporeal cardiopulmonary resuscitation (ECPR) system for refractory out-of-hospital cardiac arrest (OHCA) in Prague, compared to a historical cohort of in-hospital ECPR recipients from the Prague OHCA trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Estimated age 18-70 years
- •Refractory out-of-hospital cardiac arrest (3 unsuccessful defibrillations and/or at least 10 minutes of resuscitation in case of pulseless electrical activity)
- •Witnessed cardiac arrest
- •ECPR team available
- •ECPR team alert within 20 minutes from the emergency call
排除标准
- •Unwitnessed cardiac arrest
- •ETCO2 less than 10 mmHg upon ECPR team arrival
- •Known limitations of intensive care (Do Not Resuscitate - DNR status)
- •Known severe neurological impairment prior to cardiac arrest (mRS 4-6)
- •Suspected or known pregnancy
结局指标
主要结局
Time from collapse to ECPR
时间窗: Time from estimated collapse to start of VA ECMO flow (estimated range: 20-100 minutes)
Time from collapse to start of VA ECMO flow
次要结局
- All cause survival at 30-days(30-days)
- Modified Rankin Scale at 30-days(30-days)
研究者
Jan Bělohlávek
MD, PhD, professor
General University Hospital, Prague
研究点 (2)
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