跳至主要内容
临床试验/NCT06789978
NCT06789978招募中不适用

Prehospital Extracorporeal Cardiopulmonary Resuscitation: a Pilot Study in Prague

General University Hospital, Prague2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2025年1月20日最近更新:

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
20
试验地点
2
主要终点
Time from collapse to ECPR

研究概览

简要总结

A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA

详细描述

The aim of this pilot prospective study is to assess the feasibility and effectiveness of a prehospital extracorporeal cardiopulmonary resuscitation (ECPR) system for refractory out-of-hospital cardiac arrest (OHCA) in Prague, compared to a historical cohort of in-hospital ECPR recipients from the Prague OHCA trial.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Estimated age 18-70 years
  • Refractory out-of-hospital cardiac arrest (3 unsuccessful defibrillations and/or at least 10 minutes of resuscitation in case of pulseless electrical activity)
  • Witnessed cardiac arrest
  • ECPR team available
  • ECPR team alert within 20 minutes from the emergency call

排除标准

  • Unwitnessed cardiac arrest
  • ETCO2 less than 10 mmHg upon ECPR team arrival
  • Known limitations of intensive care (Do Not Resuscitate - DNR status)
  • Known severe neurological impairment prior to cardiac arrest (mRS 4-6)
  • Suspected or known pregnancy

结局指标

主要结局

Time from collapse to ECPR

时间窗: Time from estimated collapse to start of VA ECMO flow (estimated range: 20-100 minutes)

Time from collapse to start of VA ECMO flow

次要结局

  • All cause survival at 30-days(30-days)
  • Modified Rankin Scale at 30-days(30-days)

研究者

发起方
General University Hospital, Prague
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jan Bělohlávek

MD, PhD, professor

General University Hospital, Prague

研究点 (2)

Loading locations...

相似试验

Rapid Prehospital ACcess to ECPR in Prague | 临床试验