NCT07066605招募中不适用
The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation in Critically Ill Patients"
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Effect of Dexmedetomidine on Agitation During Weaning from Mechanical Ventilation
研究概览
简要总结
This study aims to evaluate the effect of dexmedetomidine on the level of agitation during the weaning process from mechanical ventilation in critically ill patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult ICU patients (≥18 years).
- •On mechanical ventilation ≥24 hours.
- •Clinically ready for weaning.
- •Agitation score RASS ≥ +1 during spontaneous breathing trial.
- •Intubation for at least 4 days: 2 weeks.
排除标准
- •Known hypersensitivity to dexmedetomidine.
- •Hemodynamic instability (HR < 50 bpm or MAP < 60 mmHg).
- •Neurological impairment affecting level of consciousness.
- •Pregnancy or lactation.
研究组 & 干预措施
Group A (Dexmedetomidine Group)
Active Comparator
patients will receive dexmedetomidine infusion starting at 0.2 mcg/kg/hr.
干预措施: Group A (Dexmedetomidine Group) (Drug)
Group B (Control Group)
Placebo Comparator
patients will receive standard ICU sedation protocol without dexmedetomidine (e.g., fentanyl)
干预措施: Group B (Control Group) (Drug)
结局指标
主要结局
Effect of Dexmedetomidine on Agitation During Weaning from Mechanical Ventilation
时间窗: every half an hour for two hours
Richmond Agitation-Sedation Scale
次要结局
未报告次要终点
研究者
Dalia Ayman Hussien
Resident, Department of Anesthesia, Intensive Care and Pain management, Faculty of Medicine, Sohag University
Sohag University
研究点 (1)
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