A study comparing efficacy and toxicity between 6 fractions per week radiotherapy vs 5 fractions per week radiotherapy along with weekly chemotherapy in both cases in locally advanced inoperable head and neck squamous cell cancer
Phase 2
- Conditions
- Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynxHealth Condition 2: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
- Registration Number
- CTRI/2019/10/021487
- Lead Sponsor
- Department of radiotherapy Ipgmer Sskm hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Age more than 18 yrs and below 70 years
2. Performance status: Upto ECOG-2
3. Histologically & cytologically proven SC HNC.
4. Stage: III, IV, Non-metastatic
5. Measurable & evaluable disease without any severe systematic comorbidity or uncontrolled severe haematological abnormality.
6. Given informed written consent.
Exclusion Criteria
1. Age: above 70 years.
2. Performance status: poorer than ECOG >2.
3. Stage: early stage &metastatic disease
4. Histologically any other than squamous cell carcinoma.
5. Previously treated with any type of radiation or chemotherapy: No other
previous or co-existing malignancy.
6. Any severe systemic comorbidity or sever
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To assess responsesTimepoint: 2 months
- Secondary Outcome Measures
Name Time Method To assess toxicity and survivalTimepoint: 3 Months