Mannitol to prevent an exacerbation of Complex Regional Pain Syndrome (CRPS) after hand surgery.
Completed
- Conditions
- Complex Regional Pain Syndrome
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
1. Age at least 18 jaar;
2. History of CRPS, indicated by the presence of the following characteristics during the past 3 years (adapted CRPS I criteria according to Bruehl)
Exclusion Criteria
1. Allergy to mannitol;
2. Allergy to hydrochlorothiazide;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The Impairment Level Sum Score (ISS) after 3 months, which is a composite score, accounting for pain, edema, temperature and range of motion.
- Secondary Outcome Measures
Name Time Method 1. Disability of Arm, Shoulder and Hand, Dutch Language Version (DASH-DLV) score;<br /><br>2. Individual components of ISS;<br /><br>3. Perioperative VAS-pain scores;<br /><br>4. Number of medication changes;<br /><br>5. Side effects.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie CRPS exacerbation after hand surgery and how might mannitol interfere with these pathways?
How does mannitol compare to standard-of-care treatments in preventing post-surgical CRPS exacerbations in terms of efficacy and safety?
Are there specific biomarkers that can identify patients most likely to benefit from mannitol in preventing CRPS flare-ups post-hand surgery?
What are the potential adverse events associated with mannitol administration in CRPS patients and how can they be managed?
What other compounds or combination therapies have shown promise in preventing CRPS exacerbations after hand surgery, and how does mannitol fit into this therapeutic landscape?