Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Noninvasive Ventilation for Respiratory Distress Syndrome
- Sponsor
- Mehmet Yekta
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Efficacy of nasal intermittent mandatory ventilation (IMV) and nasal continuous positive airway pressure (CPAP) in early rescue surfactant treatment in preterm infants
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The investigators aimed to compare the efficacy of nasal intermittent mandatory ventilation (IMV) and nasal continuous positive airway pressure (CPAP) in early rescue surfactant treatment in preterm infants.
Investigators
Mehmet Yekta
Zekai Tahir Burak Maternity and Teaching Hospital, Ankara
Zekai Tahir Burak Women's Health Research and Education Hospital
Eligibility Criteria
Inclusion Criteria
- •Gestational age 26-32 weeks
- •The criteria for failure were met by at least 1 of the following:
- •pH: 7.10 and PaCO2: 70 mm Hg
- •Recurrent apnea with \>3 episodes (Prophylactic caffeine were used in all infants)
- •Single episode of apnea that required bag-and-mask ventilation
- •PaO2: 50 mmHg with a fraction of inspired oxygen of \>0.5.
Exclusion Criteria
- •Major congenital anomalies
- •Presence of cardiovascular instability
- •Intubation at admission to the NICU
- •Consent not provided or refused
Outcomes
Primary Outcomes
Efficacy of nasal intermittent mandatory ventilation (IMV) and nasal continuous positive airway pressure (CPAP) in early rescue surfactant treatment in preterm infants
Time Frame: 3 months
If infants needed invasive MV or Required a fraction of inspired oxygen of \>40% to maintain the targeted saturation of \>88% to 92%, surfactant treatment will give for respiratory distress syndrome (RDS). It means that nasal IMV or CPAP is ineffective.
Secondary Outcomes
- Complications of respiratory support(3 months)