Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

Early Phase 1

Completed

• Conditions: Osteoarthritis; Exercise
• Interventions: Other: Exercise; Other: Non Exercise

• Registration Number: NCT01090375
• Lead Sponsor: Bispebjerg Hospital

Brief Summary

In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-08
• Primary Completion: 2009-03
• Status Verified: 2010-03
• Study First Submitted: 2010-03-18
• Study First Submitted QC: 2010-03-18
• Last Update Submitted: 2010-03-18
• Study First Posted: 2010-03-19
• Last Update Posted: 2010-03-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

• verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria

• dementia, inflammatory diseases, regular pain medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Exercise	Exercise	-
Non Exercise	Non Exercise	-