Evaluation and Characterisation of Microplastics and Nanoplastics in Joint Synovial Liquid

Not yet recruiting

• Conditions: Gout Arthritis; Osteoarthritis, Knee; Knee Arthritis; Microcrystal Disease

• Registration Number: NCT05678049
• Lead Sponsor: Universitatea de Medicina si Farmacie Iuliu Hatieganu

Brief Summary

The research study aims to evaluate the synovial fluid to highlight the presence of possible micropolymers (micro/nanoplastics) in order to better understand the pathophysiology of joint degenerative processes. For patients with liquid under tension at the joint level, the symptomatology often requires evacuation by puncture under ultrasound guidance. The intervention will be performed only for patients for whom this therapeutic indication exists anyway by their physician.

The investigators want to use this liquid for Microscopic and Spectrophotometric evaluation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-12-15
• Status Verified: 2023-01
• Study First Submitted QC: 2023-01-03
• Last Update Submitted: 2023-01-03
• Study First Posted: 2023-01-10
• Last Update Posted: 2023-01-10
• Study Start: 2023-01-15
• Primary Completion: 2023-12-15
• Study Completion: 2024-12-15

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• arthritis of the knee with liquid aspiration recommendation
• age >18 years

Exclusion Criteria

--refusal of the patient to participate

-age<18 years

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
nanoplastics	immediately after liquid extraction	evaluation with spectrophotometry and optic microscopy
microplastics	immediately after liquid extraction	evaluation with spectrophotometry and optic microscopy