Exploring the value of novel synovial fluid biomarkers to improve the diagnosis of patients with periprosthetic hip and knee joint infections.
- Conditions
- Revision of Total Hip Arthroplasty or Total Knee Arthroplasty
- Registration Number
- NL-OMON28263
- Lead Sponsor
- Rijnstate Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
All hospital patients planned for elective revision surgery due to failure/loosening of their THA or TKA implant will be eligible for participation provided they are willing and able to give their consent for use of their their human tissues for medical/scientific research.
Exclusion Criteria
Patients will be excluded from participation if they are planned for revision surgery due to suspected arthroplasty dislocation or malpositioning, have received intravenous and/or oral antibiotics within two weeks before the diagnostic workup, or if they have a diagnosis of a systemic inflammatory disease.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The value of flow cytometry analysis of synovial fluid as a diagnostic tool for diagnosing PJI in terms of validity, sensitivity and specificity when added to the current diagnostic scoring system (and compared to using the current diagnostic scoring system without this novel method).
- Secondary Outcome Measures
Name Time Method