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Clinical Trials/NCT05996237
NCT05996237
Completed
Not Applicable

Older Adults' Readiness to Stop Prescribed Medications With Guidance From Health Care Professionals

University of Pittsburgh1 site in 1 country108 target enrollmentSeptember 21, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Polypharmacy, Decision-making
Sponsor
University of Pittsburgh
Enrollment
108
Locations
1
Primary Endpoint
Patient Motivation to Deprescribe
Status
Completed
Last Updated
last year

Overview

Brief Summary

Polypharmacy, regular use of 5+ prescribed medications, is common among older adults and potentially harmful. Patients differ in their concern about medications, comfort in raising questions about them, and trust and confidence in physician judgment. This pilot observational research will determine older adults' readiness to "deprescribe," that is, stop prescribed medications under physician guidance.

Detailed Description

The purpose of this research is to assess readiness to deprescribe, that is, to determine how willing patients are to stop prescriptions that may no longer be necessary or may no longer have a favorable benefit-risk ratio. This readiness depends on many factors, including a patient's trust in a health care provider, how proactive patients are in seeking care, and patients' comfort in changing longstanding medical regimens. The proposed two-wave survey research will use validated instruments and recruit from an older adult research registry to determine (i) readiness to deprescribe at baseline, (ii) correlates of such readiness, and (iii) effects of intercurrent illness and changing health on readiness to deprescribe at 6 months. Specific aims: 1. Determine readiness to deprescribe among a sample of patients with 5+ prescriptions using validated scales. 2. Determine correlates of readiness to deprescribe. Patients differing in age, gender, race, education, and comorbidity may differ in willingness to stop prescribed medications. 3. Determine the effect of intercurrent illness on readiness to deprescribe. Over 6 months, we anticipate some patients will have a new onset of illness or hospitalization, or increasing levels of disability. We would like to determine if these changes in medical status affect readiness to deprescribe.

Registry
clinicaltrials.gov
Start Date
September 21, 2023
End Date
December 31, 2024
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Steven M. Albert

Professor

University of Pittsburgh

Eligibility Criteria

Inclusion Criteria

  • 65 years or older
  • Medical visit within past 6 months
  • Self-report of at least 5 regular medications for at least 4 weeks
  • Exclusion criteria:
  • Diagnosis of dementia or score \<=4 on Memory Impairment Screen
  • Hospitalization in prior 30 days with change in medications

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Patient Motivation to Deprescribe

Time Frame: Change over 6 months

Self-report measure (Linsky 2020): range 1-5; high scores = greater readiness to deprescribe; mean (SD) in VA sample 2.99 (0.80)

Secondary Outcomes

  • Self-reported stopping/changing prescription medication(6 months)

Study Sites (1)

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