Cell therapy with use of mesenchymal stem cells in infertile women with Thin Endometrium

Phase 1

Recruiting

• Conditions: Female infertility with thin endometrium.; Female infertility of uterine origin; N97.2

• Registration Number: IRCT20230222057500N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 1 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

Infertile women with thin endometrium
patient with thin endometrium for whom drugs and other treatments were ineffective
Endometrial thickness less than 7 mm
Embryo transfer is cancelled because of thin endometrium
Age between 20 and 44 years
HBsAg negative, HCV negative, HIV negative, CMV negative

Exclusion Criteria

Abnormal karyotype
Contraindications to hormone replacement therapy
Systemic diseases such as hypertension, diabetes
Other uterine diseases including uterine malformations, large myoma, endometrial tuberculosis, endometriosis
Autoimmune diseases such as rheumatoid arthritis, lupus
Unable to adhere to the follow-up

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endometrium thickness. Timepoint: Before the intervention and 1, 2 and 3 months after the first intervention. Method of measurement: Vaginal sonography.

Secondary Outcome Measures

Name	Time	Method
The effect of cell therapy on fertility rate of patients. Timepoint: 15 days after embryo transfer. Method of measurement: Using sonography and serum beta-human chorionic gonadotropin (ß-hCG) level assessment by enzyme-linked immunosorbent assay (ELISA) or chemi luminescence.