Association Between Serum Vitamin D and Postherpetic Neuralgia, A Prospective Observation Study.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 144
- 试验地点
- 1
- 主要终点
- Serum 25-hydroxyvitamin D levels
研究概览
简要总结
- The correlations of serum vitamin D level, serum calcium level and osteoporosis degree with disease severity, treatment response, incidence of Post-Herpes zoster(PHN) and disease prognosis in Herpes zoster(HZ) patients were studied.
- To investigate the role of inflammation-related factors and immune-related factors in the occurrence and development of HZ mediated by low vitamin D level.
详细描述
Herpes zoster is a neuropathic disease which induce by the varicella-herpes virus reactivation.and postherpetic neuralgia (PHN) is the most common complication. Currently,the mechanism of herpes zoster still unclearly even though there had much study about it .Vitamin D is an essential vitamin for human body, which has the function of maintaining calcium and phosphorus homeostasis and immune regulation. Vitamin D is a natural antiviral substance, and vitamin D deficiency can affect the body's antiviral ability, thereby promoting varicella-zoster virus(VZV) reactivation, and may promote the development of PHN through continuous neuroinflammation. Therefore, vitamin D level may be related to the occurrence and progression of HZ. this study intends to use an observational cohort study design to investigate the correlation of serum vitamin D level and osteoporosis degree with the severity of the herpes zoster disease, Although we plan to further explore the role of inflammatory state in this process.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years.
- •The patient was diagnosed with herpetic neuralgia and the course of disease was ≤3 months.
- •Can cooperate with the completion of inquiry and scale evaluation.
排除标准
- •Severe spinal disease (fracture, malignancy, acute or chronic infection) confirmed by previous spinal surgery or imaging.
- •Previous history of head trauma.
- •Have autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, leucothrombocytopenia).
- •Suffering from mental disorders, intellectual disability, epilepsy and other diseases.
- •A history of substance abuse, drug abuse or alcohol abuse.
- •Pregnant or breastfeeding women.
- •And recent participation in other clinical studies.
结局指标
主要结局
Serum 25-hydroxyvitamin D levels
时间窗: herpetic neuralgia <3 month
Vitamin D deficiency: \< 20 nmol/L. Vitamin D deficiency: 20-30 nmol/L. Normal vitamin D: \> 30 nmol/L.
次要结局
- C-reactive protein(Day 2 in the hospital)
- Lymphocytes(Day 2 in the hospital)
- Red blood cell distribution width,RDM(fl)(Day 2 in the hospital)
- Mean red cell volum,MVC(Day 2 in the hospital)
- Red blood cell count,RBC(Day 2 in the hospital)
- Blood glucose(Day 2 in the hospital)
- interleukinIL-8(Day 2 in the hospital)
- diastolic blood pressure,(Day 2 in the hospital)
- triglycerides(Day 2 in the hospital)
- interleukin(IL)-10(Day 2 in the hospital)
- Creatinine(Day 2 in the hospital)
- Uric acid(Day 2 in the hospital)
- Albumin(Day 2 in the hospital)
- tumor necrosis factor(TNF)-a(Day 2 in the hospital)
- cluster of differentiation 4(CD4)+(Day 2 in the hospital)
- DN4(After therapy 3 month)
- Alkaline phosphatase(Day 2 in the hospital)
- systolic blood pressure(Day 2 in the hospital)
- total cholesterol(Day 2 in the hospital)
- Cellular immune indexes C4(Day 2 in the hospital)
- magnetic resonance imaging(Day 2 in the hospital)
- cluster of differentiation 8(CD8)+(Day 2 in the hospital)
- serum Ca2+ level(Day 2 in the hospital)
- Cellular immune indexes C3(Day 2 in the hospital)
- interleukinIL-6(Day 2 in the hospital)
- Bone mineral density T value(Day 2 in the hospital)
- numeric rating scale(NRS)(After the therapy 3 month)
研究者
Feng Gao
Professor
Tongji Hospital