Optical spectroscopy as a novel tool in the diagnostics of skin neoplasms.
- Conditions
- Skin cancerskin neoplasms10040900
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 105
Inclusion Criteria
* Age 18 or over
* Clinically suspect lesion; either actinic keratosis, squamous cell carcinoma or basal cell carcinoma
* No prior treatment for the lesion
* Good understanding of Dutch or English;Additional inclusion criterion for biopsy
* Lesion size * 2 cm
Exclusion Criteria
* Prior treatment of the lesion
* Serious other illness
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Parameters that will be measured are: blood oxygen saturation, blood volume<br /><br>fraction, vessel diameter, melanin, beta-carotene and bilirubin concentration,<br /><br>autofluorescence and reduced scattering coefficient. Every parameter will be<br /><br>investigated for its difference between lesions and capability to predict the<br /><br>nature of the lesion. As a control, sun exposed or normal skin of the same<br /><br>subject is measured as well.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Nanostructural changes of the skin will be evaluated in 15 biopsies (5 per<br /><br>lesion type) using electron microscopy. Biopsy will be performed on the same<br /><br>site as the measurement. Electron microscopy of these biopsies will be related<br /><br>to the spectroscopic data.</p><br>