Are the sympathetic sensorimotor changes induced by thoracic epidural anaesthesia such that mobilization is possible?

Record Provided by the NHSTCT Register - 2006 Update - Department of Health0 sites80 target enrollmentSeptember 29, 2006

Overview

Phase: 未知
Intervention: Not specified
Conditions: Not specified
Sponsor: Record Provided by the NHSTCT Register - 2006 Update - Department of Health
Enrollment: 80
Status: Completed
Last Updated: 9 years ago

No summary available.

Registry

who.int

Start Date

September 29, 2006

End Date

TBD

Last Updated

9 years ago

Study Type

Interventional

Sex

All

Sponsor

Record Provided by the NHSTCT Register - 2006 Update - Department of Health

•All adult patients having elective thoracotomy under general anaesthesia with epidural analgesia for post operative pain relief at the Cardiothoracic Centre, Liverpool.
•The statistical calculations were done based on a similar study looking at epidural analgesia in labor in an ambulatory patient (Anesth Analg 1993;77:919\-24\). This paper suggests a failure to ambulate in 10% of the patients in the fentanyl group. A difference of 25% between this and the fentanyl/bupivacaine group would be significant clinically. With an alpha error of 5% and a power of 89% then n\=80, which is 40 patients in each group.

•1\. Patients unable to mobilize preoperatively due to pre existing neurological, cardiorespiratory or locomotor disease
•2\. Those with known autonomic nervous system dysfunction, those on beta blockers, those with moderate severe angina (Canadian Cardiovascular Society Class 3 or 4\), those with diabetes, those with known allergy to bupivacaine/ fentanyl
•3\. Routine contraindications to epidural catheter placement will apply