on-tuberculosis (TB) bacteria in patients with TB in Kampala, Uganda

Not Applicable

Active, not recruiting

• Conditions: Investigation of the microbiome of patients with tuberculosis; Not Applicable

• Registration Number: ISRCTN14141535
• Lead Sponsor: Makerere University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-03-17
• Last Update Posted: 28 March 2022
• Study Completion: 2026-12-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

New adult TB patients 18 years and older

Exclusion Criteria

1. Previously treated TB patients
2. Children

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Microbiome composition and diversity measured from stool sample using the alpha and beta diversity indices in the 'R' statistical package at baseline (time 0) and at 2, 5, 12, 18, and 24 months

Secondary Outcome Measures

Name	Time	Method
Cytokine profiles relative to the microbiome composition and diversity measured using serum/plasma, blood, stool and sputum samples using the ELISA assay at baseline (time 0)