Hyperosmolality and Acute Kidney Injury After Cardiac Surgery
- Conditions
- Acute Kidney InjuryOsmolality DisturbanceCardiopulmonary Bypass
- Interventions
- Drug: HighOsmo
- Registration Number
- NCT05914896
- Lead Sponsor
- Umeå University
- Brief Summary
The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.
- Detailed Description
Two-hundred cardiac surgical patients were randomised into two groups based on the osmolality level of the prime solution used for cardiopulmonary bypass. The high osmolality group (966 mOsm) received a prime solution containing Ringer-Acetate 1000 ml + Mannitol 400 ml (60 g) + Sodium-Chloride 40 ml (160 mmol) and Heparin 2 ml (10 000 IU), while the reference group with normal osmolality (388 mOsm) received a prime solution containing Ringer-Acetate 1400 ml and Heparin 2 ml (10 000 IU).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Patient eligible for routine cardiac surgical procedures requiring cardiopulmonary bypass.
- Patients requiring acute surgical intervention within 24 h or profound hypothermia during surgery were excluded.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description HighOsmo HighOsmo This group received a priming solution with high osmolality
- Primary Outcome Measures
Name Time Method Postoperative Acute Kidney Injury Three days Defined according to the KDIGO definition
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Public Health Clinical Medicine Umeå University
🇸🇪Umeå, Vasterbotten, Sweden