Comparison of efficacy of dexmedetomedine and subanaesthetic dose of ketamine in allaying procedural discomfort during establishment of subarachnoid block: A randomized trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1. Degree of sedation
研究概览
简要总结
Subanaesthetic doses of Ketamine has been tried for procedural sedation in the past.1, 2 Dexmedetomidine is increasingly used as a sedative drug for procedural sedation in various surgeries in recent times.3.4 There are no studies in literature comparing ketamine and dexmedetomedine for allaying procedural discomfort. So we would like to compare the efficacy of dexmeditomedine and subanaesthetic dose of ketamine in allaying procedural discomfort during establishment of subarachnoid block
Aims and objectives; To compare the efficacy of dexmeditomedine and subanaesthetic dose of ketamine in allaying procedural discomfort during establishment of subarachnoid block with regard to 1. Degree of sedation, 2. Ease of positioning, 3. Prick response 3. Time interval between study drug injection and response to verbal commands 4. Complications 5. Recall of procedure, 6. Patient satisfaction
hypothesis: dexmeditomedine is better than subanaesthetic dose of ketamine in allaying procedural discomfort during establishment of subarachnoid block
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Willingness.
- •ASA 1 & 2 physical status.
- •Age 18 to 50 years.
排除标准
- •Allergic to drugs used.
- •Psychiatric disorder.
- •Patients on beta blocker therapy.
- •Contraindicated to SAB.
结局指标
主要结局
1. Degree of sedation
时间窗: 1. during subarachnoid block look for prick response | 2. level of sedation while patient is positioned for subarachnoid block | 3. recall of spinal procedure at the end of surgery | 4. verbal response time after sedation | 5. satisfaction at the end of surgery | 6. ease of positioning after Subarachnoid block
2. Ease of positioning
时间窗: 1. during subarachnoid block look for prick response | 2. level of sedation while patient is positioned for subarachnoid block | 3. recall of spinal procedure at the end of surgery | 4. verbal response time after sedation | 5. satisfaction at the end of surgery | 6. ease of positioning after Subarachnoid block
3. Prick response
时间窗: 1. during subarachnoid block look for prick response | 2. level of sedation while patient is positioned for subarachnoid block | 3. recall of spinal procedure at the end of surgery | 4. verbal response time after sedation | 5. satisfaction at the end of surgery | 6. ease of positioning after Subarachnoid block
4.Time interval between study drug injection and response to verbal commands
时间窗: 1. during subarachnoid block look for prick response | 2. level of sedation while patient is positioned for subarachnoid block | 3. recall of spinal procedure at the end of surgery | 4. verbal response time after sedation | 5. satisfaction at the end of surgery | 6. ease of positioning after Subarachnoid block
5. Recall of procedure
时间窗: 1. during subarachnoid block look for prick response | 2. level of sedation while patient is positioned for subarachnoid block | 3. recall of spinal procedure at the end of surgery | 4. verbal response time after sedation | 5. satisfaction at the end of surgery | 6. ease of positioning after Subarachnoid block
6. Patient satisfaction
时间窗: 1. during subarachnoid block look for prick response | 2. level of sedation while patient is positioned for subarachnoid block | 3. recall of spinal procedure at the end of surgery | 4. verbal response time after sedation | 5. satisfaction at the end of surgery | 6. ease of positioning after Subarachnoid block
次要结局
- 1. complications(2. hemodynamic variation from drug administraion to patient positioning after subarachnoid block)