The Use of Mechanical Ventilation Strategies and Its Potential Adverse Events Among ICU Patients With COVID-19 - a National-wide Retrospective Observational Study.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ARDS Due to COVID-19
- Sponsor
- University of Southern Denmark
- Enrollment
- 1193
- Locations
- 2
- Primary Endpoint
- Ventilator days with lung -protective ventilation in percent of all ventilation days with 95%-CI.
- Last Updated
- 4 years ago
Overview
Brief Summary
Mechanical ventilation is likely lifesaving in patients with coronavirus disease 2019 (COVID-19) but may also result in adverse events. Only few studies describe the strategies used and adverse effect of mechanical ventilation in an unselected population of ICU patients with COVID-19.
This study is designed to be a retrospective study focusing on all mechanical ventilated ICU patients with COVID-19 included in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e. a total of 1,193 patients. The investigators will register the use of the core interventions around mechanical ventilation and its potential adverse event, including barotrauma and prolonged ventilation.
This study will provide important data on the ventilation strategies used and its potential adverse events in unselected ICU patients with COVID-19 and thereby inform clinicians, patients, policy-makers, and future research in this area.
Investigators
Anne Craveiro Brøchner
Ph D, associate professor
University of Southern Denmark
Eligibility Criteria
Inclusion Criteria
- •All mechanical ventilated patients registered in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e.
- •Admitted to an ICU in Denmark
- •Laboratory-confirmed SARS-CoV-2 infection
- •Use of invasive mechanical ventilation (ventilation via a cuffed endotracheal tube) at any time during the ICU stay
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Ventilator days with lung -protective ventilation in percent of all ventilation days with 95%-CI.
Time Frame: Until 90 days
Low tidal volume ventilation (Vt 4-8 mL/kg of predicted body weight)
Secondary Outcomes
- Number of patients with prolonged ventilation(Until 90 days)
- Prone position(Until 90 days)
- Adjuvant drugs(Until 90 days)
- The use of APRV(Until 90 days)
- Pneumothorax(Until 90 days)
- Ventilator days(Until 90 days)
- Mortality(Until 90 days)
- Time to spontaneous ventilation(Until 90 days)
- paO2/FiO2 ratio on days of ventilation(Until 90 days)
- Tracheostomy(Until 90 days)