The Use of Mechanical Ventilation Strategies and Its Potential Adverse Events Among ICU Patients With COVID-19 - a National-wide Retrospective Observational Study.
试验速览
- 阶段
- 不适用
- 入组人数
- 1,193
- 试验地点
- 2
- 主要终点
- Ventilator days with lung -protective ventilation in percent of all ventilation days with 95%-CI.
研究概览
简要总结
Mechanical ventilation is likely lifesaving in patients with coronavirus disease 2019 (COVID-19) but may also result in adverse events. Only few studies describe the strategies used and adverse effect of mechanical ventilation in an unselected population of ICU patients with COVID-19.
This study is designed to be a retrospective study focusing on all mechanical ventilated ICU patients with COVID-19 included in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e. a total of 1,193 patients. The investigators will register the use of the core interventions around mechanical ventilation and its potential adverse event, including barotrauma and prolonged ventilation.
This study will provide important data on the ventilation strategies used and its potential adverse events in unselected ICU patients with COVID-19 and thereby inform clinicians, patients, policy-makers, and future research in this area.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All mechanical ventilated patients registered in the national Danish COVID ICU database between 10.03.2020 - 02.04.2021 i.e.
- •Admitted to an ICU in Denmark
- •Laboratory-confirmed SARS-CoV-2 infection
- •Use of invasive mechanical ventilation (ventilation via a cuffed endotracheal tube) at any time during the ICU stay
排除标准
- 未提供
结局指标
主要结局
Ventilator days with lung -protective ventilation in percent of all ventilation days with 95%-CI.
时间窗: Until 90 days
Low tidal volume ventilation (Vt 4-8 mL/kg of predicted body weight)
次要结局
- Number of patients with prolonged ventilation(Until 90 days)
- Prone position(Until 90 days)
- Adjuvant drugs(Until 90 days)
- The use of APRV(Until 90 days)
- Pneumothorax(Until 90 days)
- Ventilator days(Until 90 days)
- Mortality(Until 90 days)
- Time to spontaneous ventilation(Until 90 days)
- paO2/FiO2 ratio on days of ventilation(Until 90 days)
- Tracheostomy(Until 90 days)
研究者
Anne Craveiro Brøchner
Ph D, associate professor
University of Southern Denmark