Efficiency of Daily Grapefruit Exposure in Reducing Body Weight and Inflammatory Markers
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Arizona
- Enrollment
- 85
- Locations
- 2
- Primary Endpoint
- Weight reduction
Study Overview
Brief Summary
Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles. The aims of this randomized controlled trial are to determine the role of grapefruit in:
- Reducing weight
- Reducing blood pressure
- Reducing inflammation
- Improving the lipid profile.
The investigators hypothesize that six weeks of daily consumption of grapefruit will reduce weight, blood pressure, and inflammation while improving the lipid profile in overweight, healthy adults.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Adults, men and premenopausal women
- •BMI: 25-45 kg/m2
- •Willing to maintain current exercise regimen (not to exceed 10 hours/week)
- •Willing to follow a diet low in bioactive rich fruits and vegetables and with no citrus
Exclusion Criteria
- •History of chronic disease
- •Metabolic disease
- •Inflammatory disease
- •High cholesterol (>225 mg/dL)
- •Taking medications metabolized by the Cytochrome P450 3A enzyme
- •History of alcohol or drug abuse
Outcomes
Primary Outcomes
Weight reduction
Time Frame: 6 weeks
Participants consumed 1/2 grapefruit before each meal (1.5 grapefruit per day) for six weeks. Weight was measured before and after grapefruit consumption to assess weight change. Weight change was considered statistically significant at p\<0.05.
Secondary Outcomes
- Reductions in markers of chronic inflammation(6 weeks)
- Blood pressure reduction(6 weeks)
- Lipid Profile Improvements(6 weeks)