Effect of Raspberry on Gut Microbiota and Metabolic Syndrome
- Conditions
- Gut MicrobiotaMetabolic Syndrome
- Interventions
- Dietary Supplement: Raspberry supplement
- Registration Number
- NCT03620617
- Lead Sponsor
- Laval University
- Brief Summary
There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health. Whether the beneficial effects of raspberry on obesity and the metabolic syndrome can be linked to their potential impact on the gut microbiota and intestinal integrity remains speculative at this time. Moreover, the mechanisms of action underlying health benefits associated to raspberry consumption are still unknown. The investigators are thus proposing to combine the study of metagenomics, transcriptomics and metabolomics to test whether a prebiotic activity of raspberry can play a role in the prevention of obesity-linked metabolic syndrome in a clinical setting.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 59
- Men and premenopause women in good health
- Caucasians
- At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men
- At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L
- Metabolic disorders (hypertension, diabetes, hypercholesterolemia)
- Regular use of medication affecting study parameters
- Use of natural health product in the last 3 months
- Use of antibiotics in the last 3 months
- Nicotine users
- Allergy or intolerance for raspberries
- Raspberry taste aversion
- More than 2 alcohol drinks par day
- Particular dietary habits (vegetarism, gluten-free diet, cetogenic diet...)
- Weight change of more than 5% in the last 3 months
- Surgery in the last 3 months or planed during the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental: Raspberry supplementation Raspberry supplement Dietary Supplement: 280g of frozen raspberries, taken daily for 8 weeks. Subjects will consume frozen raspberry to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and control group (without raspberry).
- Primary Outcome Measures
Name Time Method Changes in plasma insulin/glucose of overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 12 months Changes in plasma lipides/lipoproteins of overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 12 months
- Secondary Outcome Measures
Name Time Method Changes in gene expression in overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 3-6 months Changes in systolic and diastolic blood pressure of overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 12 months Changes in intestinal integrity (plasma lipopolysaccharide (LPS) and LPS binding protein (LBP) will be measured) of overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 12 months Changes in metabolites concentration in overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 3-6 months Changes in the gut microbiota composition in overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 3-6 months Changes in inflammation biomarkers of overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group). 12 months
Trial Locations
- Locations (1)
Laval University
🇨🇦Québec, Quebec, Canada